Wednesday, May 1, 2013

Flagler professor heading to Israel to study terrorism

400-WILL-MILLER-FLAGLERThe Foundation for the Defense of Democracies, a non-partisan policy institute headquartered in Washington, D.C., announced to Historic City News in St Augustine that Will Miller, a professor of public administration at Flagler College, has been named an academic fellow for 2013-14.

Miller will travel to Israel next month for an intensive course in terrorism studies, and in particular, how democracies can defeat the worldwide terrorist threat.

?As a country, we have again seen just this week the dire impact acts of terrorism can have on members of our society,? said Miller. ?My experiences in learning will allow me to return to the classroom and my research better able to help search for answers that could expedite the elimination of threats to our country ? from both domestic and international enemies.?

The Academic Fellows program provides a 10-day learning experience to US-based teaching and research professionals to give them cutting edge information about defeating terrorist groups. The program will be conducted at Tel Aviv University and includes lectures by academics, military and intelligence officials, as well as diplomats from Israel, Jordan, India and the United States. It also includes ?hands on? experience through visits to police, customs and immigration facilities, military bases and border zones to learn the practical side of deterring and defeating terrorists.

Miller is currently working with University of Akron professor Karl Kaltenthaler and Georgetown University professor Christine Fair on an 18-month study funded by the US Department of State to better understand the relationship between media consumption in Pakistan and beliefs about the legitimacy of Islamist violence.

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Source: http://www.historiccity.com/2013/staugustine/news/florida/flagler-professor-heading-to-israel-to-study-terrorism-36252

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The Guantánamo Memoirs of Mohamedou Ould Slahi

U.S. Military Police guard Taliban and al Qaeda detainees in orange jumpsuits January 11, 2002 in a holding area at Camp X-Ray at Naval Base Guantanamo Bay, Cuba during in-processing to the temporary detention facility. This file photo shows in-processing at Camp X-Ray in Guant?namo Bay, Cuba in 2002.

Photo by Petty Officer 1st class Shane T. McCoy/U.S. Navy/Getty Images

In July 2003, as Slahi?s ?special interrogation? continued, Guant?namo commander Maj. Gen. Geoffrey Miller added another brutal ruse to Slahi?s interrogation plan. Following days of intensive questioning, Slahi was to be forcibly removed from his cell by a team of military police in riot gear, escorted past menacing dogs, and loaded onto a helicopter, where he would be flown out over the ocean and threatened with death or rendition to a Middle Eastern country?a threat to be made all the more real by the presence of Egyptian and Jordanian interrogators on the flight. The general?s plan was subsequently revised because, as his intelligence chief later told Justice Department investigators, ?Miller had decided that [the helicopter] was too difficult logistically to pull off, and that too many people on the base would have to know about it to get it done.? Instead, on Aug. 24, 2003, in accordance with the plan that Defense Secretary Donald Rumsfeld ultimately signed, Slahi was abducted from his cell and taken on a three-hour boat trip into the Caribbean, where he was beaten and threatened by U.S. military personnel and two Arab interrogators.

I barely finished my meal, when all of a sudden [ ? ? ? ? ?] and I heard a commotion, guards cursing loudly, ?I told you, motherfucker ?,? people banging the floor violently with heavy boots, dog barking, doors closed loudly. I froze in my seat. [ ? ? ? ? ?] went speechless. We were staring at each other, not knowing what was going on. My heart was pounding because I knew a detainee was going to be hurt. Yes, and the detainee was me.

Suddenly a commando team of three soldiers and a German shepherd broke into our interrogation room. [ ? ? ? ? ?] punched me violently, which made me fall face down on the floor, and the second guy kept punching me everywhere, mainly on my face and my ribs. Both were masked from head to toe.

?Motherfucker, I told you, you?re gone!? said [ ? ? ? ? ?]. His partner kept punching me without saying a word; he didn?t want to be recognized. The third man was not masked, he stayed at the door holding the dog collar, ready to release it on me.

?Who told you to do that? You?re hurting the detainee,? screamed [ ? ? ? ? ?], who was no less terrified than I was.

As to me, I couldn?t digest the situation. My first thought was, they mistook me for somebody else. My second thought was to try to look around, but one of the guards was squeezing my face against the floor. I saw the dog fighting to get loose. I saw [ ? ? ? ? ?] standing up, looking helpless at the guards working on me.

?Blindfold the motherfucker! He?s trying to look?? One of them hit me hard across the face and quickly put goggles on my eyes, earmuffs on my ears, and a small bag over my head. They tightened the chains around my ankles and my wrists; afterward I started to bleed. All I could hear was [ ? ? ? ? ?] cursing, ?F-ing this and F-ing that.? I thought they were going to execute me.

The other guard dragged me out with my toes tracing the way, and threw me in a truck, which immediately took off. The beating party would last for the next three to four hours, before they turned me over to another team that would use different torture techniques.

?Stop praying, motherfucker. You?re killing people,? [ ? ? ? ? ?] said, and punched me hard on my mouth. My mouth and nose started to bleed, and my lips grew so big that I technically could not speak anymore. The colleague of [ ? ? ? ? ?] turned out to be one of my guards; [ ? ? ? ? ?] and [ ? ? ? ? ?] each took one of my sides and started to punch me and smash me against the metal of the truck. One of the guys hit me so that my breath stopped and I was choking. I felt like I was breathing through my ribs.

Did I pass out? Maybe not. All I know is that I kept noticing [ ? ? ? ? ?] several times spraying ammonia in my nose. The funny thing was, Mr. [ ? ? ? ? ?] was at the same time a ?lifesaver,? as were the guards I would be dealing with for the year to come; all of them were allowed to give me medication and first aid.

After 10 to 15 minutes, the truck stopped at the beach. My escort team dragged me out of the truck and put me in a high-speed boat. [ ? ? ? ? ?] never gave me a break; they kept hitting me.

?You?re killing people,? said [ ? ? ? ? ?]. I believe he was thinking out loud: He knew he was committing the most cowardly crime in the world, torturing a helpless detainee who was completely submissive and turned himself in. [ ? ? ? ? ?] was trying to convince himself that he was doing the right thing.

Inside the boat, [ ? ? ? ? ?] made me drink salt water, I believe it was direct from the ocean. It was so nasty I threw it up. They put an object in my mouth and shouted, ?Swallow, motherfucker!? I decided inside not to swallow the organ-damaging salt water, which choked me as they kept pouring the water in my mouth. ?Swallow, you idiot!? I contemplated quickly, and decided for the nasty, damaging water rather than death.

[ ? ? ? ? ?] and [ ? ? ? ? ?] had been escorting me for about three hours in the high-speed boat. The goal of such trip was, first, to torture the detainee and claim that the ?detainee hurt himself during transport,? and second to make the detainee believe he is being transferred to some far faraway secret prison. We detainees knew all about this; we had detainees who reported flying four hours and finding themselves in the same jail where they started. I knew from the beginning that I was going to be transferred to [ ? ? ? ? ?].

When the boat [landed], [ ? ? ? ? ?] and his colleague dragged me out and made me sit cross-legged. I was moaning from the unbearable pain.

?Uh ? Uh ? ALLAH. ALLAH ? I told you not to fuck with us, didn?t I?? said Mr. X, mimicking me. I hoped I could stop moaning because the gentleman kept mocking me and blaspheming the Lord; however the moaning was necessary so I could breathe. ?We appreciate everybody who works with us, thanks gentlemen,? said [ ? ? ? ? ?]. I recognized his voice. Although he was addressing his Arab guests, the message was addressed to me more than anybody.

It was nighttime. My blindfold didn?t keep me from feeling the bright lighting, some kind of high-watt projectors.

?We happy for zat. Maybe we take him to Egypt, he say everything,? said an Arab guy whose voice I?d never heard, with a thick Egyptian accent. I could tell the guy was in his late 20s or early 30s based on his voice, his speech, and later on his actions. His English was both poor and decidedly mispronounced.

Then I heard indistinct conversations here and there, after which the Egyptian and another guy approached. Now they?re talking directly to me in Arabic.

?What a coward! You guys ask for civil rights? You get none,? said the Egyptian.

?Somebody like this coward, it takes us only one hour in Jordan until he spits everything,? said the Jordanian. Obviously he didn?t know that I had spent eight months in Jordan and no miracle took place.

?We take him to Egypt,? said the Egyptian, addressing [ ? ? ? ? ?].

?Maybe later,? said [ ? ? ? ? ?].

When I heard Egypt, and a new rendition, my heart was pounding. I hated the endless world tour I was forcibly taking. I thought that rendition to Egypt on the spot was possible, because I knew how irritated and desperate the Americans were when it came to my case.

After all kinds of threats and degrading statements, I missed a lot of the trash talk between the Arabs and their American accomplices. At one point, I drowned in my thoughts. I felt ashamed that my people were being used for this horrible job by a government that claims to be the leader of the democratic free world, a government that preaches against dictatorship and ?fights? for human rights and sends its children to die for that purpose. What a joke this government makes of its own people! What would the dead-average American think if he or she saw what his or her government is doing with someone who has done no crimes against anybody?

If people in the Arab world knew what is happening in this place, the hatred against the U.S. would be heavily watered, and the accusation that the U.S. helps and works together with dictators in our countries would be cemented. I had a feeling, or rather a hope, that these people would not go unpunished for their crimes. The situation didn?t make me hate either the Arabs or the Americans; I just felt bad for the Arabs.

After about 40 minutes, I couldn?t really tell, [ ? ? ? ? ?] instructed the Arabic team to take over. The two guys grabbed me roughly and since I couldn?t walk on my own, they dragged me on the tips of my toes to the boat. I must have been very near to the water because the trip to the boat was short. I don?t know, but either they put me in another boat or in a different seat. The seat was both hard and straight.

?Move, fucker!? They gave this order and knew that I was too hurt to be able to move. After all I was bleeding from my mouth, my ankles, my wrists, and maybe my nose, I could not tell for sure. But the team wanted to maintain the factor of fear and terror.

?Sit!? said the Egyptian guy, who did most of the talking, while both were pulling me down until I hit the metal. The Egyptian sat on my right side, and the Jordanian on my left. ?What?s your fucking name?? asked the Egyptian. ?M-O-OH-H-M-M-EE-D-D-O-O-O-O-U!? I answered. Technically, I couldn?t speak because of my swollen lips and hurting mouth. You could tell I was completely scared. Usually I wouldn?t talk when somebody started to hurt me. This is a milestone in my interrogation history. In Jordan, when the interrogator smashed my face, I refused to talk, ignoring all his threats.? You can tell I was hurt like never before, that it is not me anymore, and I will never be the same as before. A thick line was drawn between my past and my future with the first hit [ ? ? ? ? ?] did to me.

A side mounted SAW "machine gun" is at the ready at members of a US Coast Guard security detail, in a Viper fast boat, patrol the waters of Guantanamo Bay, Cuba 23 April 2007 at sunset. A U.S. Coast Guard security detail patrols the waters of Guant?namo Bay, Cuba in 2007.

Photo by Paul J. Richards/AFP/Getty Images

?He is like a kid,? said the Egyptian, accurately addressing his Jordanian colleague. I felt warm between them, though not for long, because with the cooperation of the American, a long trip of torture was being prepared.

They put on a kind of thick jacket, which fastened me to the chair. It was a good feeling?however there was a destroying drawback to it. My chest was so tightened that I couldn?t breathe properly. Plus, the air circulation was worse than the first trip. I didn?t know what exactly but something was definitely going wrong. ?I c?a?n?t br?e?a?the!?

?Suck the air,? said the Egyptian wryly. I was literally suffocating inside the bag around my head.

The order went as follows: They stuffed the air between my clothes and me with ice cubes from my neck to my ankles, and whenever the ice melted they put in new hard ice cubes. Moreover, every once in a while, one of the guards smashed me, most of the time in the face. The ice served both for pain and for wiping out the bruises I had from that afternoon. Everything seemed to be perfectly prepared. Historically, dictators during medieval and pre-medieval times used this method to let the victim die slowly.? The other method of hitting the victim while blindfolded in inconsistent intervals of time was used by Nazis during WWII. There is nothing more terrorizing than making somebody expect a smash every single heartbeat.

?I am from Hasi Matruh, where are you from?? said the Egyptian, addressing his Jordanian colleague. He was speaking as if nothing was happening. You could tell he was used to torturing people.

?I am from the south,? answered the Jordanian.

What would it be like if I landed in Egypt after about 25 hours of torture? What would the interrogation look like? [ ? ? ? ? ?], a [ ? ? ? ? ?], described to me his unlucky trip from Pakistan to Egypt. Everything I was now experiencing?ice cubes and smashing?was consistent with [ ? ? ? ? ?]'s story. So I expected electric shocks in the pool. How much power can my body, especially my heart, handle? I know something about electricity and its devastating, irreversible damage. I saw [ ? ? ? ? ?] collapsing in the block a couple of times every week with blood gushing out of his nose until it soaked his clothes. [ ? ? ? ? ?] was a martial arts trainer and athletically built.

But what if they don?t believe me? No, they would believe me, because they understand the recipe of terrorism more than the Americans and have more experience. Americans tend to widen the circle of involvement to catch the most possible number of Muslims. They always speak about the big conspiracy against the U.S. I personally had been asked who practiced the basics of the religion and sympathized with Islamic movements; no matter how moderate the movement, I had been asked to prove every detail about it. That is very amazing in a country such as the U.S., where Christian terrorist organizations such as Nazis and white supremacists have the freedom to express themselves and recruit people openly and nobody can bother them, while as a Muslim if you sympathize with the political views of an Islamic organization you?re in big trouble. Even attending the same mosque as a suspect brings big trouble. I mean this fact is clear for everybody who understands the ABCs of American policy toward the so-called Islamic terrorism.

Source: http://feeds.slate.com/click.phdo?i=1d7956ccfdcc625d64ce6ea72eca9af6

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Tuesday, April 30, 2013

Is Fame to Blame For 'Teen Mom' Stars' Scandals?

MTV's Teen Mom was supposed to show the tough reality of being a teenage parent -- but right now, parenthood seems like the least of the cast's problems. Jenelle Evans, 21, was arrested last week for heroin possession and assault. Farrah Abraham has just sold her sex tape, made shortly after she was arrested for DUI at the end of March. And of course, they're now feuding...over who's a better mother. Sigh.

Source: http://www.ivillage.com/teen-mom-trouble-farrah-abrahams-sex-tape-jenelle-evans-heroin-arrest/1-a-534559?dst=iv%3AiVillage%3Ateen-mom-trouble-farrah-abrahams-sex-tape-jenelle-evans-heroin-arrest-534559

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Stocks flip between gains and losses

Specialist John Parisi, right, works at his post on the floor of the New York Stock Exchange Tuesday, April 30, 2013. Stock prices are opening mostly lower on Wall Street as weak earnings from Pfizer and other companies drag down major market averages. (AP Photo/Richard Drew)

Specialist John Parisi, right, works at his post on the floor of the New York Stock Exchange Tuesday, April 30, 2013. Stock prices are opening mostly lower on Wall Street as weak earnings from Pfizer and other companies drag down major market averages. (AP Photo/Richard Drew)

Trader Daniel Kryger works on the floor of the New York Stock Exchange Tuesday, April 30, 2013. Stock prices are opening mostly lower on Wall Street as weak earnings from Pfizer and other companies drag down major market averages. (AP Photo/Richard Drew)

Trader Fred DeMarco, left, works on the floor of the New York Stock Exchange Tuesday, April 30, 2013. Stock prices are opening mostly lower on Wall Street as weak earnings from Pfizer and other companies drag down major market averages. (AP Photo/Richard Drew)

Specialist Matthew Diez, left, and trader Michael Zicchinolfi work on the floor of the New York Stock Exchange Tuesday, April 30, 2013. Stock prices are opening mostly lower on Wall Street as weak earnings from Pfizer and other companies drag down major market averages. (AP Photo/Richard Drew)

(AP) ? Weak earnings from Pfizer and other companies held back major market indexes on Tuesday, as the Standard & Poor's 500 flipped between slight gains and losses.

Pfizer's stock dropped 3 percent after the drug maker's results fell short of what analysts had expected, a result of currency movements and falling sales. The world's second-largest drug maker also cut its profit forecast for the rest of the year.

Pfizer lost 97 cents to $29.46, among the biggest drops in the Dow Jones industrial average. Shortly after noon, the Dow was down 16 points at 14,802, a decline of 0.1 percent.

The Standard & Poor's 500 index was flat at 1,593. The index closed at a record high the day before.

Brad Sorensen, director of market research at the brokerage Charles Schwab, said that trading would likely be quiet Tuesday except for companies reporting earnings. Later this week, investors will hear from the Federal Reserve and the European Central Bank and get the U.S. government's monthly job report. Investors are often reluctant to take big positions ahead of potentially market-moving events such as those.

"People are probably taking a breath today," he said. "We're waiting for some more important events to happen later in the week."

The Nasdaq composite index rose 11 points to 3,317, an increase of 0.3 percent.

Pitney Bowes sank 16 percent after the maker of mailing equipment and software cut its dividend in half and posted a 58 percent drop in net income. Pitney Bowes sank $2.59 to $13.61.

Avon Products' quarterly loss wasn't as deep as analysts had expected. The direct-seller of cosmetics has been cutting staff and scaling back operations in an effort to turn around its business. Avon's stock rose 71 cents to $22.96, a gain of 3 percent.

This earnings season has been a mixed bag. More than half of the companies in the S&P 500 have turned in results, and seven of 10 have beaten analysts' estimates for earnings, according to S&P Capital IQ. Nearly as many, however, have come up short on revenue: Six of 10 have missed analysts' revenue targets. That suggests companies are getting more of their profits from laying off staff and other cost-cutting efforts instead of from higher sales.

In the market for U.S. government bonds, the yield on the 10-year Treasury note dropped to its low for the year, 1.65 percent. That's down from 1.67 percent late Monday.

In response to slower economic growth, bond traders from around the world have been buying Treasurys this month, driving yields down. The 10-year yield started April trading around 1.85 percent.

The Dow and the S&P 500 are on track to end the month with gains of 1.6 percent. It wasn't exactly a smooth ride. The two indexes reached record highs in the second week of April, then took a steep fall in the next. News that China, the world's second-largest economy, slowed unexpectedly pummeled the prices of oil, copper and other commodities. The stock market had its worst day of the year on April 15, when the S&P 500 lost 2.3 percent.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-30-US-Wall-Street/id-09680deb425342298bed02fa983df0e8

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Russia caught bomb suspect on wiretap

WASHINGTON (AP) ? Russian authorities secretly recorded a telephone conversation in 2011 in which one of the Boston bombing suspects vaguely discussed jihad with his mother, officials said Saturday, days after the U.S. government finally received details about the call.

In another conversation, the mother of now-dead bombing suspect Tamerlan Tsarnaev was recorded talking to someone in southern Russia who is under FBI investigation in an unrelated case, officials said.

The conversations are significant because, had they been revealed earlier, they might have been enough evidence for the FBI to initiate a more thorough investigation of the Tsarnaev family.

As it was, Russian authorities told the FBI only that they had concerns that Tamerlan and his mother were religious extremists. With no additional information, the FBI conducted a limited inquiry and closed the case in June 2011.

Two years later, authorities say Tamerlan and his brother, Dzhohkar, detonated two homemade bombs near the finish line of the Boston Marathon, killing three and injuring more than 260. Tamerlan was killed in a police shootout and Dzhohkar is under arrest.

In the past week, Russian authorities turned over to the United States information it had on Tamerlan and his mother, Zubeidat Tsarnaeva. The Tsarnaevs are ethnic Chechens who emigrated from southern Russia to the Boston area over the past 11 years.

Even had the FBI received the information from the Russian wiretaps earlier, it's not clear that the government could have prevented the attack.

In early 2011, the Russian FSB internal security service intercepted a conversation between Tamerlan and his mother vaguely discussing jihad, according to U.S. officials who spoke on condition of anonymity because they were not authorized to discuss the investigation with reporters.

The two discussed the possibility of Tamerlan going to Palestine, but he told his mother he didn't speak the language there, according to the officials, who reviewed the information Russia shared with the U.S.

In a second call, Zubeidat Tsarnaeva spoke with a man in the Caucasus region of Russia who was under FBI investigation. Jacqueline Maguire, a spokeswoman for the FBI's Washington Field Office, where that investigation was based, declined to comment.

There was no information in the conversation that suggested a plot inside the United States, officials said.

It was not immediately clear why Russian authorities didn't share more information at the time. It is not unusual for countries, including the U.S., to be cagey with foreign authorities about what intelligence is being collected.

The FSB said Sunday that it would not comment.

Jim Treacy, the FBI's legal attache in Moscow between 2007 and 2009, said the Russians long asked for U.S. assistance regarding Chechen activity in the United States that might be related to terrorism.

"On any given day, you can get some very good cooperation," Treacy said. "The next you might find yourself totally shut out."

Zubeidat Tsarnaeva has denied that she or her sons were involved in terrorism. She has said she believed her sons have been framed by U.S. authorities.

But Ruslan Tsarni, an uncle of the Tsarnaev brothers and Zubeidat's former brother-in-law, said Saturday he believes the mother had a "big-time influence" as her older son increasingly embraced his Muslim faith and decided to quit boxing and school.

After receiving the narrow tip from Russia in March 2011, the FBI opened a preliminary investigation into Tamerlan and his mother. But the scope was extremely limited under the FBI's internal procedures.

After a few months, they found no evidence Tamerlan or his mother were involved in terrorism.

The FBI asked Russia for more information. After hearing nothing, it closed the case in June 2011.

In the fall of 2011, the FSB contacted the CIA with the same information. Again the FBI asked Russia for more details and never heard back.

At that time, however, the CIA asked that Tamerlan's and his mother's name be entered into a massive U.S. terrorism database.

The CIA declined to comment Saturday.

Authorities have said they've seen no connection between the brothers and a foreign terrorist group. Dzhohkar told FBI interrogators that he and his brother were angry over wars in Afghanistan and Iraq and the deaths of Muslim civilians there.

Family members have said Tamerlan was religiously apathetic until 2008 or 2009, when he met a conservative Muslim convert known only to the family as Misha. Misha, they said, steered Tamerlan toward a stricter version of Islam.

Two U.S. officials say investigators believe they have identified Misha. While it was not clear whether the FBI had spoken to him, the officials said they have not found a connection between Misha and the Boston attack or terrorism in general.

___

Associated Press writer Adam Goldman in Washington and Michael Kunzelman in Boston contributed to this report.

Source: http://news.yahoo.com/russia-caught-bomb-suspect-wiretap-105240857.html

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Monday, April 8, 2013

Sony MDR-1R


Sony's forays into headphones of late have often been focused on boosted bass, or even co-branding with television shows (like the X Factor), so it's refreshing to see a no-nonsense, high quality pair like the MDR-1R. At $299.99 (direct), it's priced for serious music lovers, and its sound signature, with powerful-yet-refined bass response and crisp highs, does not disappoint. The design is visually pleasing, well-constructed, and comfortable, and includes thoughtful features like detachable cables. There are no ugly surprises here?the MDR-1R doesn't distort at top volumes, nor does it lean too heavily in favor of deep bass.

Design
The design of the MDR-1R is graceful, with the simple black matte, shiny metallic-colored surfaces, and luxurious-looking padded leather all combining to create a classic backdrop for the familiar Sony logo. A touch of bright red is used on the ear cups, and it elevates the look from stately to cool. If there's a complaint, it's only that some of the materials feel a little cheap for a model of this price?but they don't look cheap, and they function perfectly.

The headband, for instance, is not only well-padded and extremely comfortable, but adjusting it is an unusually smooth and graceful process?it's easy, using the stop-clicks, to get the proper-fitting size and keep it. Equally comfortable are the circumaural (around-the-ear) ear-pads, which feel almost like pillows. Swivel joints above the ears allow for the headphones to fit even more seamlessly, pivoting to the shape of your head. The headphones also fold down flat for easier packing and toting.Sony MDR-1R inline

That the cable, which connects to the left ear, is detachable adds value to the MDR-1R?but the inclusion of two cables, one with an inline microphone and remote?even further solidifies the headphones as a solid investment. Since cables are often the first part of the headphone equation to malfunction over time, being able to swap them out, rather than replace the whole unit or send it in for repair, is a money saver.

Call clarity is solid enough?the mic picks up voices well, and the headphones block out a bit of ambient room sound (passively), allowing for clearer conversations. But, this is cellular audio quality we're talking about, so don't expect it to sound stellar.

Along with the two cables, the MDR-1R ships with a drawstring protective carrying pouch. Surprisingly, there's no 1/4-inch headphone jack adapter for stereos and pro-gear, nor is there an airline jack adapter. These exclusions on a pair this pricey are annoying, but if you need them, the problem can easily be remedied at a Radio Shack for cheap.

Performance
At top (and unsafe) listening volumes, the MDR-1R reproduces deep bass effectively and cleanly?there's no distortion on The Knife's sub-bass-laden "Silent Shout", and at this price, there shouldn't be. The manual claims that the frequency range of the MDR-1R is 4Hz to 80kHz, which is bound to make some audiophiles snicker?typical adult human ears top out at the high-end of the frequency spectrum anywhere from 15-20kHz, depending on the listener, so we'll just have to take Sony's word for it that these headphones extend a full 60,000 Hertz beyond the limits of human hearing.

Even the low end of the MDR-1R's range is unusually low?it's not terribly common to see a pair dip below 10Hz in the realm of subwoofer bass response, but these headphones apparently reproduce sub-bass frequencies all the way down to 4Hz. (You have a much better chance of hearing those frequencies than ones hovering around 80kHz.)

These potentially dubious claims shouldn't scare the serious listener off, however?the MDR-1R packs a robust, yet refined, bass response. If it does indeed go all the way down to 4Hz, it does so without needlessly boosting the bass beyond sensible limits. There's perhaps more bass than someone seeking flat response might want, but this is not an outrageously bass-boosted pair by any means.

On Bill Callahan's "Drover," the MDR-1R strikes an ideal balance between the low frequencies, high-mids, and treble. Callahan's vocals on this track can sound muffled on a bass-heavy pair that lacks enough treble edge, or overly sibilant on a pair that tweaks the high-mids and highs too much. Here, his unique baritone vocals have a smoothness and edge all at once, while the drumming receives a nice bit of low-end boost without threatening to take the spotlight.?

On Jay-Z and Kanye West's "No Church in the Wild", the kick drum loop's attack has enough high-mid presence to sound punchy, while its sustain is rounded out by the MDR-1R's smooth low-frequency response. The sub-bass synth hits that lend this song an ominous feeling are conveyed accurately here?not overly-boosted so that the mix sounds off-balance, but certainly with some added oomph. If anything, both Callahan's and this track might have benefited from the slightest bit of boosting in the high-mids, to add an extra bit of crispness to the vocals and snap to the percussion?but this is nitpicking. The MDR-1R sounds pretty fantastic.

On classical tracks, like John Adams' "The Chairman Dances", the higher register strings already possess enough high-mid crispness to fend for themselves. The lower register strings are given a nice, subtle boost, adding a sense of depth to the mix. The huge drum hits at the end, which can sound comically unnatural on heavily bass-boosted headphones, sound large and intense here, without venturing into a realm of fake mega-bass. The MDR-1R, in other words, suits classical music quite well.

If you're looking in this general price range, and you want that added bass depth that the MDR-1R's reigned-in sound signature lacks, you have options. The less expensive Denon Urban Raver AH-D320 and the SMS Audio Street by 50 DJ both pack healthy, boosted low frequency wallops.

If you just want to explore other similar options in this range, the Yamaha PRO 400, which doesn't boost things nearly as intensely, shifts the focus to the midrange. Its styling isn't as classy as the MDR-1R's, but sonically, the pairs are comparable. If you have a local electronics store that can make it happen, it might be worth a head-to-head comparison to see which you favor most, as it's about personal taste and not overall quality at this point. And if all of these pairs are out of your range, consider the excellent, Editors' Choice Sennheiser HD 558, a sonic marvel at a sub-$200 price.?

At $300, the Sony MDR-1R delivers powerful audio with focus on overall balance. It could use a bit more high-mid presence, and bass lovers will wish there was more low-end boosting, but the sound signature comes close to the audiophile ideal of flat response, without throwing bass presence out the window. There's no question of whether these are high quality headphones; it's merely whether their sound signature is what you're looking for.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/amSfEnbqmOM/0,2817,2417268,00.asp

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Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination

Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination [ Back to EurekAlert! ] Public release date: 7-Apr-2013
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Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

WASHINGTONA novel combination of two drugs has shown anti-cancer activity in patients who had incurable solid tumors and carried a germline mutation in their BRCA genes, Dana-Farber Cancer Institute researchers are reporting at the American Association for Cancer Research annual meeting in Washington, April 6-10.

The findings (abstract LB-202) will be released at a press conference on Sunday, April 7, 2 p.m. ET, and later at an oral presentation on Tuesday, April 9, 2 p.m. ET, in Room 153, in the Washington Convention Center.

The two oral drugs, sapacitabine and seliciclib, were given sequentially in a phase 1 clinical trial that is mainly enrolling patients whose tumors lack BRCA function because of an inherited mutation.

"We have seen several responses among these patients, as well as instances of prolonged stable disease lasting more than a year," said Geoffrey Shapiro, MD, PhD, director of Dana-Farber's Early Drug Development Center (EDDC). As a result, he said that a BRCA mutation may be a potential biomarker that identifies patients who are more likely to respond to the drug combination.

Sixteen patients enrolled in the trial carried an inherited BRCA mutation. Four of these patients had partial responses a 30 percent or greater shrinkage of tumor mass including one with pancreatic, two with breast, and one with ovarian cancer. Three patients were continuing to have a partial response at the time of presentation of the data, with the longest lasting more than 78 weeks. Two additional BRCA mutation carriers, with breast and ovarian cancer, experienced stable disease for 21 and 64 weeks, respectively. Of the remaining 22 patients enrolled in the trial, six experienced stable disease for 12 weeks or more.

Sapacitabine is toxic to cancer cells by causing damage to their DNA, which, if not repaired, causes the cells to self-destruct. The BRCA protein is essential for repair of the DNA damage caused by sapacitabine, so patients with mutations that inactivate BRCA may be more sensitive to the drug's activity.

The second drug, seliciclib, is an inhibitor of cyclin-dependent kinases (CDKs), enzymes that have multiple cellular functions, including a role in DNA repair, further augmenting the effects of sapacitabine. The patients in the trial received sapacitabine twice daily for seven days, followed by seliciclib twice daily for three days. Adverse events were mild to moderate in intensity, the study found.

Shapiro and colleagues are continuing to enroll BRCA mutation carriers in the trial, and hope to determine if the mutations may serve as a biomarker for response. He said that these drugs may prove to be an important treatment alternative for patients with BRCA-deficient cancers.

###

This research was supported in part by Cyclacel Ltd., and the National Institutes of Health (RO1 CA90687).

--Written by Richard Saltus, Dana-Farber Cancer Institute

About Dana-Farber Cancer Institute

Dana-Farber Cancer Institute is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. It provides adult cancer care with Brigham and Women's Hospital as Dana-Farber/Brigham and Women's Cancer Center and it provides pediatric care with Boston Children's Hospital as Dana-Farber/Children's Hospital Cancer Center. Dana-Farber is the top ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Facebook: http://www.facebook.com/danafarbercancerinstitute and on Twitter: @danafarber.


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Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination [ Back to EurekAlert! ] Public release date: 7-Apr-2013
[ | E-mail | Share Share ]

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

WASHINGTONA novel combination of two drugs has shown anti-cancer activity in patients who had incurable solid tumors and carried a germline mutation in their BRCA genes, Dana-Farber Cancer Institute researchers are reporting at the American Association for Cancer Research annual meeting in Washington, April 6-10.

The findings (abstract LB-202) will be released at a press conference on Sunday, April 7, 2 p.m. ET, and later at an oral presentation on Tuesday, April 9, 2 p.m. ET, in Room 153, in the Washington Convention Center.

The two oral drugs, sapacitabine and seliciclib, were given sequentially in a phase 1 clinical trial that is mainly enrolling patients whose tumors lack BRCA function because of an inherited mutation.

"We have seen several responses among these patients, as well as instances of prolonged stable disease lasting more than a year," said Geoffrey Shapiro, MD, PhD, director of Dana-Farber's Early Drug Development Center (EDDC). As a result, he said that a BRCA mutation may be a potential biomarker that identifies patients who are more likely to respond to the drug combination.

Sixteen patients enrolled in the trial carried an inherited BRCA mutation. Four of these patients had partial responses a 30 percent or greater shrinkage of tumor mass including one with pancreatic, two with breast, and one with ovarian cancer. Three patients were continuing to have a partial response at the time of presentation of the data, with the longest lasting more than 78 weeks. Two additional BRCA mutation carriers, with breast and ovarian cancer, experienced stable disease for 21 and 64 weeks, respectively. Of the remaining 22 patients enrolled in the trial, six experienced stable disease for 12 weeks or more.

Sapacitabine is toxic to cancer cells by causing damage to their DNA, which, if not repaired, causes the cells to self-destruct. The BRCA protein is essential for repair of the DNA damage caused by sapacitabine, so patients with mutations that inactivate BRCA may be more sensitive to the drug's activity.

The second drug, seliciclib, is an inhibitor of cyclin-dependent kinases (CDKs), enzymes that have multiple cellular functions, including a role in DNA repair, further augmenting the effects of sapacitabine. The patients in the trial received sapacitabine twice daily for seven days, followed by seliciclib twice daily for three days. Adverse events were mild to moderate in intensity, the study found.

Shapiro and colleagues are continuing to enroll BRCA mutation carriers in the trial, and hope to determine if the mutations may serve as a biomarker for response. He said that these drugs may prove to be an important treatment alternative for patients with BRCA-deficient cancers.

###

This research was supported in part by Cyclacel Ltd., and the National Institutes of Health (RO1 CA90687).

--Written by Richard Saltus, Dana-Farber Cancer Institute

About Dana-Farber Cancer Institute

Dana-Farber Cancer Institute is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. It provides adult cancer care with Brigham and Women's Hospital as Dana-Farber/Brigham and Women's Cancer Center and it provides pediatric care with Boston Children's Hospital as Dana-Farber/Children's Hospital Cancer Center. Dana-Farber is the top ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Facebook: http://www.facebook.com/danafarbercancerinstitute and on Twitter: @danafarber.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/dci-spw040513.php

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