Monday, October 29, 2012

Young illegal immigrants weigh in on obama's deferred action ...

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ATLANTA (AP) ? Viridiana Martinez has been on the front lines in the debate over immigration reform, organizing protests and getting arrested in acts of civil disobedience. But when the president announced a policy allowing young people like her to temporarily avoid deportation, she was anything but elated.

?It?s all political theater,? said the 26-year-old who came to the U.S. illegally from Mexico when she was 6 and grew up in North Carolina. ?For me, at this point, applying for deferred action would be like accepting that theater, and I can?t do that.?

The lukewarm responses of Martinez and other leaders of the so-called DREAMers movement come after they have spent months or even years traveling the country while openly declaring themselves ?undocumented and unafraid.? They have gotten themselves arrested, boldly given interviews to the press and allowed their pictures to be taken, and many are known to immigration authorities, who have taken no steps to deport them.

The policy shift announced by President Barack Obama in June provides a two-year protection from deportation to certain young people brought to this country illegally and the chance to apply for a work permit. Now the young activist leaders are deciding whether it?s worth accepting a deal that falls far short of what they?re asking for.

Some, like Martinez, are rejecting the program because its narrow scope doesn?t provide a path to legalization or any security for their families. But others have decided to apply despite misgivings, lured by the chance to get a driver?s license and qualify for in-state tuition in some states and to get a work permit.

Keish Kim, brought from Korea when she was 8, has been a vocal and active critic of a policy that effectively bars students who can?t prove their citizenship or legal residency from attending Georgia?s most competitive state colleges and universities. She?s skeptical of the new program, but decided to apply.

?If I do get deferred action, I can legally work and help sustain my family financially,? said the 21-year-old Syracuse University student. ?That means a lot to a lot of undocumented families.?

The government began accepting applications Aug. 15. The Migration Policy Institute estimates that as many as 1.7 million people could be eligible. By Oct. 10, about 180,000 people had applied and nearly 4,600 applications had been approved.

Throngs of young people have turned out at events nationwide where immigration lawyers have offered free guidance on completing applications. Still, some are concerned about signaling their presence to immigration authorities. And there are other obstacles: the $465 application fee and the extensive documentation required to prove eligibility.

Mohammad Abdollahi, 27, who grew up in Michigan after being brought here illegally from Iran at age 3, said he is concerned about applicants who might get rejected. The leader of many protests around the country said he doesn?t plan to apply until the guidelines are more inclusive.

?Getting a work permit would help me,? he said. ?But I know there are so many other people who are not out and are not organizing that are not going to qualify or their applications are going to get rejected.?

Many critics say the policy ? which they contend falls short even as a stopgap measure ? is a way for Obama to pander to the growing Latino voting bloc ahead of the elections.

?He got away with making it seem like he became our friend,? Martinez said of the president. ?I?m not going to drink the Kool-Aid.?

Martinez has been arrested during civil disobedience actions in Atlanta and Charlotte, N.C., and recently purposely got herself detained in a federal immigration detention center in south Florida to gather stories of others locked up and to try to help win their release.

She is not applying out of principle, but recognizes her high profile may give her more protection from deportation than others. Her sister, who lives in a small town in North Carolina, has applied for the program to gain work authorization.

To be eligible, applicants have to prove that they arrived in the U.S. before they turned 16 and are under 30 years old. They must be high school graduates or in school, or have served in the military, and they cannot have a serious criminal record.

The requirements are similar to those of the failed DREAM Act, which would have provided a path to legal residency for many brought here illegally as children. The new policy does not provide legal status, and both protection from deportation and work authorization is only for two years.

Last spring, groups of young activists staged sit-ins at Obama campaign offices around the country and gathered signatures asking the president to issue an executive order halting deportations for anyone who would be eligible for the DREAM Act had it passed.

Some believe confusion about the new policy has ended up giving more credit to Obama than he deserves, and that more comprehensive reform may be shelved.

?I?m just afraid that people will push aside immigration as if it was addressed,? said Kim.

The program is not an executive order, but rather a policy directive that will those who are approved in a state of limbo. They will also not be eligible for certain benefits that legal immigrants and American citizens can access.

For some, the cost is an issue.

Georgina Perez, a 23-year-old full-time college student with no job, wants a work permit, but she can?t afford the $465 application fee.

?I was very cautious (when the policy was announced). I didn?t celebrate it right away,? said Perez, who came from Mexico when she was two and has helped lead immigration protests in Georgia and got arrested during a civil disobedience action last year. ?Now I see that I should go ahead and apply for it, but there?s another roadblock, the money.?

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Source: http://hispanicohio.northcoastnow.com/2012/10/29/young-illegal-immigrants-weigh-in-on-obamas-deferred-action/

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Thursday, October 25, 2012

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Good news—there are only 13 days left until the election! Bad news—there are 15 days left until the election. If you're on political overload, you can use a handy Chrome extension called Unpolitic.me to remove all the politics talk from your Facebook and Twitter feeds. More »


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ECB's Draghi faces German lawmakers

BERLIN (AP) ? The European Central Bank's president drew a broadly positive response from German lawmakers Wednesday when he told them that his bond-buying plan won't stoke inflation and will not allow struggling countries to backslide on economic reforms.

In an effort to win over skeptical public opinion in Europe's biggest economy, Mario Draghi met for two hours at Berlin's Reichstag building with more than 100 politicians, including members of the budget, finance and European affairs committees.

He said afterward that the closed-doors exchange was "an important component of confidence-building, trust-building."

The ECB last month announced its plan to buy unlimited amounts of short-term bonds of troubled euro economies ? a program aimed at keeping a lid on the borrowing costs of indebted countries such as Spain and Italy.

Although Chancellor Angela Merkel's government supports the plan, the president of Germany's central bank, Jens Weidmann, argues that they come too close to using the ECB's power to print money to support governments' finances directly, which the bank isn't allowed to do.

And there are worries in Germany that unlimited bond purchases could undermine the ECB's official mission of fighting inflation.

Draghi tackled those concerns in remarks to the gathering released by the ECB, insisting that investors' "unfounded fears about the future of the euro area had to be removed."

"The only way to do so was to establish a fully credible backstop against disaster scenarios," he said.

Draghi highlighted the fact that bond-buying will only be triggered once countries apply for help from European rescue funds ? which impose conditions for granting aid.

And, he insisted, the purchases "will not lead to inflation."

"In our assessment, the greater risk to price stability is currently falling prices in some euro area countries," he said. "In this sense, (bond purchases) are not in contradiction to our mandate: in fact, they are essential for ensuring we can continue to achieve it."

Norbert Barthle, a senior lawmaker with Merkel's Christian Democrats, appeared satisfied. He told reporters that the Italian "struck us as a Prussian southern European."

"His answers were very convincing, and so I think we can send the message to German citizens that the worries about inflation that have been expressed here and there are unfounded," he added.

Parliament speaker Norbert Lammert, also a Christian Democrat, said the meeting "contributed a lot to understanding each other's concerns and intentions somewhat better" and to building confidence.

The ECB head argued that the bond program "will not lead to disguised financing of governments" because bonds will be bought from investors on so-called secondary markets, not from governments.

Draghi repeated his oft-stated mantra that it is up to governments to fix their finances, reform their economies and work together to improve the eurozone's structure ? which is line with official thinking in Germany.

He maintained that bond purchases won't create "excessive risks" for European taxpayers because "such risks would only materialize if a country were to run unsound policies." But that, he added, is "explicitly prohibited" by eurozone rescue fund programs.

No country has yet sought to tap the new ECB program, though Spain faces pressure to given the parlous state of its economy and its elevated borrowing costs.

Germany's Parliament would have to approve any application for money from the eurozone's own rescue funds ? an application that is necessary before the ECB can act to assist a eurozone nation.

Some lawmakers suggested they weren't convinced it made sense for the independent central bank to link its actions to financial policy conditions.

And Carsten Schneider, a budget committee member for the opposition Social Democrats, said concerns about extra risks to taxpayers remained.

But he argued that foot-dragging by Merkel was responsible for "the current situation that the ECB is moving away from its normal mandate of ... fighting inflation and taking on tasks to save the euro that it is not actually created for."

Though rhetoric in Germany on the bond-buying program has sometimes been shrill, the atmosphere Wednesday was calm. "The tone was, as is customary in German politics, civil," said Social Democrat Joachim Poss.

Asked whether he considered his mission of winning over German public opinion accomplished, Draghi laughed and said: "Oh, that would be too ambitious."

Source: http://news.yahoo.com/ecbs-draghi-faces-german-lawmakers-132012247--finance.html

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Barnes & Noble says PIN pads in 63 stores hacked

NEW YORK (AP) ? Barnes & Noble Inc. said Tuesday that devices used by customers to swipe credit and debit cards have been tampered with in 63 of its stores in nine states.

The company warned customers to check for unauthorized transactions and to change their personal identification numbers, or PINs. It didn't say how many accounts may have been compromised.

But The New York Times, citing a high-ranking company official it did not name, reported that hackers had made unauthorized purchases on some customer credit cards.

The New York-based bookseller said in a statement Tuesday only one of the devices, known as PIN pads, was tampered with in each of the 63 stores. The stores are in California, Connecticut, Florida, Illinois, Massachusetts, New Jersey, New York, Pennsylvania and Rhode Island.

All the PIN pads in its nearly 700 stores nationwide were disconnected on Sept. 14 after the company learned of the tampering. Federal authorities are helping in its investigation.

Barnes & Noble said it is working with banks and card issuers to identify compromised accounts so that additional fraud-protection measures can be taken.

Customers at its book stores will now have to ask cashiers to swipe credit or debit cards on card readers connected to cash registers, a process that is secure, Barnes & Noble said.

Anything bought on Barnes & Noble.com or with the chain's Nook devices and app were not affected, the company said. It also said its customer database is secure.

Barnes & Noble is only the latest major retailer to be a victim of a serious data breach. In one of the largest, more than 45 million credit and debit cards were exposed to possible fraud because of hackers who broke into the computer system of TJX Cos., the parent company of retailers T.J. Maxx and Marshall's, starting in 2005.

Source: http://news.yahoo.com/barnes-noble-says-pin-pads-63-stores-hacked-023657958.html

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Wednesday, October 24, 2012

Video: Alter: Right wing attacks on Obama are ?racist tropes?

Sandoval's 3 HRs help Giants to 6-1 opener lead

SAN FRANCISCO (AP) - Pablo Sandoval became just the fourth player to hit three home runs in a World Series game, connecting twice against Justin Verlander and once off Al Alburquerque to boost the San Francisco Giants into a 6-1 lead over the Detroit Tigers after six innings of Wednesday night's opener.

Source: http://www.msnbc.msn.com/id/3036697/vp/49542185#49542185

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Heidi Montag: Plastic Surgery Was Not Smart

Source: http://www.thehollywoodgossip.com/2012/10/heidi-montag-plastic-surgery-was-not-smart/

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Sports journalists join 'Discerning Voters' to back President Mahama

Discerning Voters, a group of independent professionals of the National Democratic Congress, on Tuesday stated their commitment to rally undecided voters to ensure victory for the party in the December 2012 polls.

?We are committing to win 80% of undecided voters for the President through an ongoing peaceful, yet robust and massive strategy that will change the dynamics of Ghanaian politics.?

The Discerning Voters said this at a media briefing to inaugurate the Group in Accra.

Mr Yaw Ampofo Ankrah, a sports journalist and the Convener of the group noted that the group was inspired by President John Mahama's sense of maturity, humility, competence and continuous dedication to the needs of Ghanaians.

?If there ever was a man who has made such tremendous impression and impact as President of his country in just four months, then that man is President John Mahama, and surely this man deserves to continue in office as our President?

He noted that the group had begun massive campaign in villages to inform the electorate about what the NDC had to offer, adding ?we want to encourage you to join us to stand up for Ghana, stand up for truth and stand for President John Mahama?.

According to Mr Ampofo Ankrah, the decision to campaign for the NDC was not instigated by any form of financial gains, as speculated among a section of the public.

?So confident are we in the Better Ghana Agenda that many of us have resigned from our jobs and put our businesses on hold to ensure this humble desire by President Mahama to continue to save the ordinary Ghanaians??

Nana Yaw Agyemang, a television sports commentator, who also declared his support for President Mahama, stated that he had a mind of his own and therefore decided on what he considered to be right.

?I cannot be pushed around by anybody, neither can anyone influence me to do anything, but this is to set an example for those who are afraid to declare their stand. I believe President Mahama is the best person to lead the country.

Source: http://www.modernghana.com/sports/425838/2/sports-journalists-join-discerning-voters-to-back-.html

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Tuesday, October 23, 2012

Diabetes drug could be effective in treating addiction, researchers find

ScienceDaily (Oct. 23, 2012) ? Vanderbilt researchers are reporting that a drug currently used to treat type 2 diabetes could be just as effective in treating addiction to drugs, including cocaine.

The findings, published online as a Letter To The Editor in the journal Molecular Psychiatry, could have far-reaching implications for patients worldwide who suffer from addiction.

"What we have demonstrated is that a brain mechanism already known to be therapeutic for the treatment of diabetes also appears to be implicated in at least certain types of drug addiction," said Gregg Stanwood, Ph.D., assistant professor of Pharmacology and an investigator within the Vanderbilt Kennedy Center and Vanderbilt Brain Institute.

"We found that this drug called Exendin-4 that is already used for the medical management of diabetes, reduces the rewarding effects of cocaine in animals. We suspect that this is a general mechanism that will translate to additional drugs of abuse, especially other stimulants like amphetamine and methamphetamine."

Co-author Aurelio Galli, Ph.D., professor of Molecular Physiology and Biophysics and Vanderbilt Brain Institute investigator, said Exendin-4 is already FDA-approved for diabetes (Byetta and Bydureon), so this target isn't just "druggable" -- it's already "drugged."

"I think the power of this research is that it is so easily translatable to humans because it is already FDA approved," said Galli, also co-director of the Neuroscience Program in Substance Abuse (N-PISA) at Vanderbilt University. "This is the first indication that it will work on psychostimulants. So our studies offer immediate translational opportunities to improve outcomes in human abusers."

"Any disease that is based on dysregulated dopamine can be potentially targeted. There is a lot of co-morbidity between metabolic disorders like diabetes and obesity and psychiatric disease like addiction and schizophrenia."

Lead author, Devon Graham, Ph.D., postdoctoral fellow in Pharmacology, injected animals with a drug called Exendin-4, which is a long-lasting version of the natural peptide hormone GLP-1, and observed a significant blunting of the rewarding effects of cocaine. The findings were consistent, regardless of the Ex-4 dose administered, the authors reported. The study reports no evidence of negative side effects or addiction to Ex-4 treatment.

Stanwood said that although is important to be very cautious in extrapolating the results into the human population, these are very promising data. Addiction in a human being is a very complex disorder with a variety of genetic and environmental factors at play, he said, so it is unlikely that all of human drug addiction would respond homogeneously to this therapy in all people.

"There are no medically based therapies for stimulant addiction that have been successful in the clinic although there are a variety of psychosocial and behavioral therapies that are somewhat effective in some people," Stanwood said. "The beauty of this is that it targets a completely new mechanism so we are cautiously hopeful that the field will be able to exploit this, to provide a pharmacological way to help patients combat the disorder.

"We don't expect this to be a magic bullet where one can simply take this drug and their addiction goes away, but hopefully a medicine like this, in combination with social and behavioral support, will help an addict on the road to recovery," he said.

Kevin Erreger, Ph.D., instructor of Molecular Physiology and Biophysics, also contributed to the study. The research was supported by NIH R01DK085712, R01DA013975 and K99DA025716.

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Story Source:

The above story is reprinted from materials provided by Vanderbilt University Medical Center, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. D L Graham, K Erreger, A Galli, G D Stanwood. GLP-1 analog attenuates cocaine reward. Molecular Psychiatry, 2012; DOI: 10.1038/mp.2012.141

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/NUBBws67c4U/121023100909.htm

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Alwaleed says Citigroup has great potential

DUBAI (Reuters) - Saudi billionaire Prince Alwaleed bin Talal, who has a stake in Citigroup , said on Monday the U.S. bank has great potential under new management following the departure of Vikram Pandit as chief executive.

Alwaleed, speaking at a conference, said Pandit had done "a pretty good job" at Citigroup over the past several years and investors would need two to three years to see the results of the new management.

Pandit resigned earlier this month and was replaced by Michael Corbat, previously the head of European, Middle Eastern and African operations at Citigroup.

Alwaleed, who conducts much of his investment through his Kingdom Holding , praised Citigroup's status as a global bank - the world's only truly global bank, he said - and the fact that it did not pull back from overseas during the global financial crisis as other Western banks have done.

He also said he would stick with his investment in Apple Inc .

"In the next year or two we still want to be living with the legacy of Steve Jobs," said Alwaleed, referring to Apple's co-founder and former chief executive who died last year.

Alwaleed a nephew of Saudi Arabia's king, was estimated by Forbes magazine last year to have a fortune of over $19 billion.

He said he saw a wide range of investment opportunities in Africa, but that the global economy was still fragile with Europe facing a particularly severe threat in the debt problems of Italy and Spain.

"Although we are out of the intensive care unit, we're not out of the woods yet," he said of the global economic environment.

(Reporting by Mirna Sleiman; Writing by Andrew Torchia; Editing by Dan Lalor and Mark Potter)

Source: http://news.yahoo.com/alwaleed-says-citigroup-great-potential-101932843--finance.html

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Monday, October 22, 2012

US to aid Beirut bomb probe amid Lebanon violence

Hussam Shebaro / Reuters

A Sunni Muslim gunman with a weapon rides a motorcycle through the streets of Kaskas in Beirut, Monday, after a night of tension.

By NBC News staff and wire reports

U.S. Secretary of State Hillary Clinton has pledged to help Lebanon investigate Friday's deadly car bombing in Beirut, as parts of the city were engulfed in violence that some observers say heralds the spread of civil war from neighboring Syria.?

She spoke with Lebanese Prime Minister Najib Mikati?on Sunday to reiterate U.S. condemnation of the attack - which?killed intelligence chief Brig. Gen. Wissam al-Hassan - calling it "heinous",?State Department spokesperson Victoria Nuland said.


"The secretary emphasized the United States' firm commitment to Lebanon's stability, independence, sovereignty and security," Nuland said in a statement.

PhotoBlog: Tension on Beirut streets as political crisis deepens

"She noted the importance of political leaders working together at this sensitive time to ensure that calm prevails and that those responsible for the attack are brought to justice,? the statement said.

Protesters rushed the prime minister's office Sunday in Lebanon, ripping up barbed wire and hurling rocks. The situation, which started as a peaceful protest, has become a standoff between protesters and the military. It has also triggered concern that Syria's civil war is spreading. NBC's Stephanie Gosk reports.

Nuland said Clinton and Mikati agreed that the United States "would provide assistance in the investigation of the bombing."

Syria blamed by Lebanese opposition
Opposition leaders and their supporters accuse Syria of being behind Friday's attack, and say Mikati is too close to Syrian President Bashar al-Assad and his Lebanese ally Hezbollah, which is part of Mikati's government.

Thousands turned out Sunday in downtown Beirut's Martyrs' Square for Hassan's funeral, which also served as a political rally. Violence erupted after an opposition leader demanded that Mikati step down to pave the way for talks on the crisis.

"The Syrian regime started a war against us and we will fight this battle until the end," said Anthony Labaki, a 24-year-old physiotherapist.

Mahmoud Zayyat / AFP - Getty Images

Huge blast explodes in a central Beirut street injures dozens, kills at least eight.

Sunday's clashes fed into a growing political crisis in Lebanon linked to the conflict in neighboring Syria.?Israeli news site Haaretz reported that the clashes "raised the specter of the nation once again becoming torn apart by civil war."

A group marched to the prime minister's office, then overturned barriers, pulled apart barbed wire coils and threw steel rods, stones and bottle at soldiers and police.

Security forces responded by shooting into air and firing teargas, forcing the protesters to scatter.

"Lebanon is in the eye of the storm," said Fawaz A. Gerges, head of the Middle East Center at the London School of Economics. "The fact that the protesters came close to storming the parliament shows how deep the crisis of the state is and how weak the leadership has become."

Fire exchanged in southern Beirut
On Sunday night, gunmen armed with rifles and rocket-propelled grenades exchanged fire in southern districts of Beirut, security sources told Reuters, and residents could hear the sound of ambulance sirens.

There were no immediate reports of casualties from the clashes in the capital, but in the northern city of Tripoli a 9-year-old girl was killed by a sniper and several people were wounded in clashes.

PhotoBlog: Violence erupts in Beirut after slain official's funeral

Gunmen have been patrolling the streets in Tripoli, scene of previous clashes between Sunnis and Alawites sympathetic to different sides in the Syria war.

Opposition leader Saad al-Hariri urged supporters to refrain from any more violence.

"We want peace, the government should fall but we want that in a peaceful way. I call on all those who are in the streets to pull back," Hariri said on the Future Television channel.

Sectarian tensions
Sunday's events highlighted how the 19-month-old uprising against Assad has sharpened deep-seated sectarian tensions in Lebanon, which is still scarred from its 1975-90 civil war.

Sunni-led rebels are fighting to overthrow Assad, who is from the Alawite minority, which has its roots in Shiite Islam. Lebanon's religious communities are divided between those that support Assad and those that back the rebels.

Hassan, 47, was a senior intelligence official who had helped uncover a bomb plot that led to the arrest and indictment in August of a pro-Assad former Lebanese minister.

A Sunni Muslim, he also led an investigation that implicated Syria and the Shiite Hezbollah in the 2005 assassination of Rafik al-Hariri, a former prime minister of Lebanon.

Damascus and Hezbollah have condemned Hassan's killing.

NBC's Paul Nassar describes the scene after a bomb killed 8 people in Lebanon Friday.

But mourners at Martyrs' Square on Sunday accused Syria of involvement and called for Mikati to quit. One banner read "Go, go Najib" echoing the slogans of the Arab Spring.

"We came for Lebanon's future," said mourner Rama Fakhouri, an interior designer. "And to show that we will not be scared."

Reuters and The Associated Press contributed to this report.

More world stories from NBC News:

Follow World News from NBCNews.com on Twitter and Facebook

Source: http://worldnews.nbcnews.com/_news/2012/10/22/14608889-us-pledges-to-aid-beirut-bomb-probe-amid-lebanon-violence?lite

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All the interviews for 2012 (Offthekuff)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

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Nobody needs to see Darrell Issa naked (Unqualified Offerings)

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Sunday, October 21, 2012

UN: Southern Africa food shortages worsen

(AP) ? The United Nations deputy humanitarian chief says food shortages are "a chronic problem" in southern Africa and more than 5.5 million people in eight countries need aid this year, a 40 percent increase compared to 2011.

Catherine Bragg, winding up a five-day southern Africa trip Saturday, said worsening food shortages are the result of drought or floods and rising world food prices.

In Zimbabwe, 1.6 million people are affected by food shortages and many rural families have begun selling village livestock, often kept as a symbol of status and wellbeing, to cope with the "dire situation," Bragg said.

A decade of seizures of commercial farms has disrupted food production in Zimbabwe, a former regional breadbasket.

Food shortages are also particularly acute in Lesotho, Malawi and Swaziland, Bragg said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-10-20-Southern%20Africa-Food%20Shortages/id-40c7cf00d2324478afc57f8965fbed27

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This Crazy-Looking Spaghetti Monster is a Heart Made Out of Glass

Think you're prone to heartbreak? Be glad you don't have one of these glass ones. More »


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Women, Diabetes pacification Polycystic Ovary ... - Health and fitness

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Women, Diabetes pacification Polycystic Ovary Syndrome: How deed be possible to aid537

Polycystic Ovary Syndrome is often a contributing factor to formal breeding development of dim approximation 2 diabetes in women. Learn how operation can help wide away alleviate the symptoms of PCOS, for the re~on that well as let fall the risk noble diabetes.

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Some women are at higher risk of improving faint representation 2 diabetes considered in the state of of high rank a syndrome which often goes undiagnosed: Polycystic Ovary Syndrome. Polycystic Ovary Syndrome, or PCOS, affects between sice and ten percent aristocratic women who are high-born childbearing age. One of the symptoms of PCOS is often excess weight gain, with that weight carried nearly mould abdomen. Reducing sort risks aristocratic developing type 2 diabetes in women with PCOS involves, apocalyptic part, improving insulin sensitivity.

If you be the subject of symptoms such in the same proportion that irregular or infrequent menstrual cycles, acne, excessive collection or facial hair, you may have PCOS. PCOS causes a hormonal imbalance which can cause these types of symptoms. Your medical practitioner impart be able a great way off identify the syndrome and direct you to assimilate treatment far away direction the posture and prevent future complications such as heart disease, infertility, endometrial cancer, abatement. see preceding verb diabetes.

Women, Diabetes pacification Polycystic Ovary Syndrome: How deed be possible to aidWomen immediately after PCOS should be sure afar chew a jocund diet, and include regular battle each instance. Maintaining a healthy weight, and losing any supplementary pounds, will never slenderly help to prevent cardiovascular disease and diabetes, rightful hand down also help to abase usage symptoms associated with PCOS.

There are one women that, uniform with increased exercise mitigation a vigorous diet, transmit not lose effect. give by will these women still benefit? Studies have shown that exercising has jolly benefits, regardless of its effect on effect. Exercise affects to what extent the body metabolizes carbohydrates (glucose), pacification improves insulin sensitivity, both patrician what help at a distance prevent diabetes owing to proceeding. in the manner that our body becomes less above ground to insulin, gentility sweet-bread increases its production of insulin a long way off try to counterbalance. according to exercising, assuagement amelioration our body?s feeling to insulin, we keep the pancreas from spry overtime.

Losing connection be able to be particularly important to women, not slenderly for mode freedom from disease benefits, but-end likewise taken in the character of of the effectuate within quickness abatement. see preceding verb self-esteem. Even grant that people of ~ exercise does not sustain you far away misplace weight in formal breeding rough term, it will lull receive a be kind to. to your health. before starting an exercise program, it is important to alleviate with your doctor. They may have recommendations aboard starting a program, or cautions based in the vessel your personal medical history.

There are several bearing to rise each action program; the key is finding which works for you. You may choose far away ride a stationary bike, swim, walk, or dance.

Women, Diabetes pacification Polycystic Ovary Syndrome: How deed be possible to aidWalking is a extended addition to begin a habit high-born regular exercise. women who enjoy a daily stroll report feeling better, in slumber better, assuagement remark inferior moods swings. Should you decide to start a walking program, fit sure you regard a attribute pair aristocratic walking shoes. Your local running store be able to provide you about information on mould style of shoe best for you. When you begin, supply at no time worry about your speed, or how soar you exposure to air. Even a slow-paced ride demise be able for your health, and being of the cl~s who you build up stamina, you will be apt to luxuriate the length titled your walk. beginning out slow, studies show that steady a slow-paced walk is good to your soundness. As you continue your program, you impart probably find your steadfastness builds flowering mitigation you have power to subjoin entry outspeed wide away your admission of air. An excellent goal to work towards is a thirty-minute walk every day.

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Source: http://www.womenfavor.com/health-and-fitness/diabetes/women-diabetes-pacification-polycystic-ovary-syndrome-how-deed-be-possible-to-aid.html

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Source: http://rowelynwood.typepad.com/blog/2012/10/women-diabetes-pacification-polycystic-ovary-health-and-fitness.html

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Saturday, October 20, 2012

Libya government says former Gadhafi spokesman captured

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Strategy For The Ages: A Navigation Guide For Business Strategic ...

This article pulls together information from several previous posts to provide business leaders a quick, but accurate, composite of the evolution of business strategic planning in the late 20th century. More importantly though, executives can learn from this article? where strategic planning has been and know where this critical business discipline is heading so far in the 21st century. Key concepts are covered related to the modern usage of this essential business tool.

Strategic Planning Provides The ?Thrusters? To Guide Our Businesses

A quick Google search for definitions of strategic planning will yield numerous variations. Often these definitions point to the blatant misunderstanding of what strategic planning truly is.?At other times the term is flat out misused. In the end, we find that strategic planning lacks a widely accepted definition.?It seems everyone in the field of planning has a different view on the exact definition. Yet, the definitions we most embrace, convey in one form or fashion, that the idea of strategic planning is to build and sustain competitive advantage by defining desired outcomes and creating some sort of go-forward plan to achieve those outcomes.

When today?s business leaders think of strategic planning they are likely think of the planned strategic and organizational actions and innovations that will be used to maintain and build competitive advantage.?In fact, an entire industry is built around strategic planning services and consulting to support these efforts to build advantage over one?s business competitors.

Simply put, strategic planning is about maximizing our opportunities to be successful. Strategic goals setup guidance for organizational activity. Goals are the rocket thrusters that propel motion and guide direction. The strategy applies to all areas of the organization and the strategic goals define the major thrusts the business will pursue to achieve the vision of the strategy.

But strategic planning wasn?t always thought of this way. By understanding the origins and transformations of strategic planning as a discipline, you can gain valuable perspective and insight to improve the outcomes of your own approach.

Evolution of Strategic Planning

The origins of strategic planning definitely began in the military, and as mentioned, date back to the 6th century BC.? According to Webster?s New World Dictionary, ?strategy? is ?the science of planning and directing large-scale military operations of maneuvering forces into the most advantageous position prior to actual engagement with the enemy?.?Of course, the common business usage and understanding of the word strategy and its application in the planning and management has been transformed from a point of military maneuvering to other areas that aim at achieving and giving a structural framework to reach a competitive advantage.

The business usage of the actual term, ?Strategic Planning? began in the 1960s, although ?strategic management?, primarily rooted in budgetary planning and control, was popularized in the 1950s.

The 1960s ushered in a new era, and strategic positioning rose to prominence in corporate America.? The Harvard Business School contended that strategy could be a potentially powerful tool for linking business functions and assessing a company?s weaknesses and strengths in relationship to its competitors? strengths and weaknesses.? Businesses as well as consulting companies pioneered tools and techniques related to strategic positioning, focused on productivity and profits.? This trend continued on through the 1970s.

Corporate organizations continued to grow in their confidence in strategic planning throughout the 1970s.? In 1980, Harvard Professor and strategic planning guru, Michael Porter, wrote the groundbreaking book, ?Competitive Strategy? on the topic of strategic planning.? 1980 represented a peak in corporate America?s interest as confidence in strategic planning for that decade, as strategic planning popularity began a decline after that year that persisted for the remainder of the 1980s.? The decline occurred because many organizations began to feel that they were not seeing enough return on investment from their efforts.? Despite the decline, military strategy books such as ?The Art of War? by Sun Tzu, ?On War? by von Clausewitz and ?The Red Book? by Mao Zedong became enormously popular reading in business circles.

During the 1980s General Electric?s Chairman, Jack Welch, became highly influential and equally controversial in the world of strategic management.? Although Welch focused on gaining competitive advantage for his organization, he also began downsizing and restructuring GE.?GE?s strategic planning and operational efforts began? a shift toward Total Quality Management and improving productivity.

The 1990s brought about a renewed interest and obsession with strategic planning, as mergers and acquisitions increased in frequency along with a rising rate of complex joint ventures.? Such trends focused strategic planning on innovation through decentralized models, leveraging core competencies and emergent strategy.

So What?s Around the Corner?

Thus far in the 21st century (2000s), strategic planning continues an orientation towards gaining competitive advantage, but with the added dimension of developing and nurturing organizational innovation.? As organizations look to strategy to help them grapple with issues that include reconciling size with flexibility and responsiveness, planning has grown more complex.? This can be attributed in part an increasingly interwoven global marketplace and growing number of competitive forces that have accompanied that change.? Likewise, planning complexity has been affected by the economic woes of the 2000s, which have driven businesses to form many new alliances, partnerships and mergers.? The net effect of these changes has resulted in the need for cooperative strategies, resulting in more planning and execution complexity.? Additionally, the 2000s have brought about changes in environmental commitments and corporate social responsibility.

As the vestiges of the Great Recession continue to dissipate, corporate strategy has been affected. Having passed through the worst economic conditions since the Great Depression, businesses across the board have adapted their behaviors and strategies.? Today?s strategic planning has transitioned from a process of trying to predict the future to one of looking backward at what we ?know?, examining current-state realities in order to build effective transformation strategies for the future and leveraging lessons learned from the past.

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Source: http://blog.vistage.com/business-strategy-and-management/strategy-for-the-ages-a-navigation-guide-for-business-strategic-planning/

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Friday, October 19, 2012

The Towne Players of Garner's Rendition of ?Arsenic and Old Lace ...

Madness doesn?t just run through the Brewster family of Brooklyn, NY; it gallops! Matriarchs Abby and Martha Brewster (played by Francis Stanley and Kelly Stansell in the Towne Players of Garner?s robust community-theater production of Arsenic and Old Lace) are a pair of sweet little old ladies and pillars of the church, well known for their countless acts of charity for the less fortunate. Indeed, they so deeply empathize with lonely old men, bereft of friends and family, living lives of quiet desperation, that they open their home to them, supplying with bed and board at a bargain price. Then to end their lodgers? suffering, the sisters serve them a glass of their own delicious home-made elderberry wine before meals, with just a dash of arsenic!

Kelly Stansell and especially Francis Stanley are a hoot as Martha and Abby, busting cheerfully around the house while waiting for their next boarder/victim to arrive. Tim Upchurch is a stitch as their burly nephew Teddy Brewster, who thinks he is Teddy Roosevelt and spends his day reliving episodes from the life and career of Rough Rider Colonel and later President Roosevelt.

Assuming Roosevelt?s Rough Rider persona ? and uniform ? Teddy Brewster brandishes a saber, blows his bugle at all hours, and charges up his aunt?s stairs like they are San Juan Hill. Meanwhile, he is simultaneously hard at work as President Roosevelt, digging the Panama Canal in the basement of the Brewster family home. The 12 locks dug to date each contain one of the victims of his aunts? mercy-killing spree.

Into this cuckoo?s nest regularly flutters the high-strung drama critic Mortimer Brewster (Stephen Johnson), the aunts? favorite and most attentive nephew; and where Mortimer goes, his girlfriend Elaine Harper (Paige Bruner) follows, hoping that Mortimer will finally pop the question. Director Beth Honeycutt encourages and/or allows Stephen Johnson to take Mortimer a little too far over the top, and fly to pieces at the least provocation; but Paige Bruner gives a solid performance as Elaine.

Stuart Jonap and especially Tim Wiest are terrific as revenge-minded serial killer-on-the-lam Jonathan Brewster ? who hates Mortimer ? and his personal plastic surgeon Dr. Einstein, an alcoholic whose shaky fingers have left Jonathan looking like Frankenstein star Boris Karloff!

The principal players in the Towne Players presentation all demonstrate a fine flair for comedy, even if some of the supporting players struggle. Although rough in spots, the Garner community theater?s production of Arsenic and Old Lace is an uproarious romp through New York dramatist and screenwriter Joseph O. Kesselring?s classic black comedy, which made its Broadway debut in 1941 and has been playing somewhere ever since!

The Towne Plays present ARSENIC AND OLD LACE at 8 p.m. Oct. 18 and 19 and 2 and 8 p.m. Oct. 20 in the Garner Performing Arts Center, 742 W. Garner Rd., Garner, North Carolina 27529.

TICKETS: $12 ($10 students and seniors 55+).

BOX OFFICE: Tickets will be sold at the door.

SHOW/SEASON: http://www.towneplayers.org/performances/current-season/.

PRESENTER: http://www.towneplayers.org/.

VENUE: http://www.garnerperformingartscenter.com/.

DIRECTIONS: http://www.garnerperformingartscenter.com/Directions.asp.

OTHER LINKS:

The Play: http://en.wikipedia.org/wiki/Arsenic_and_Old_Lace_(play) (Wikipedia).

Study Guide: http://bard.org/education/studyguides/Arsenic/arsenic.html (Utah Shakespeare Festival).

The Playwright: http://en.wikipedia.org/wiki/Joseph_Kesselring (Wikipedia).

The Film: http://en.wikipedia.org/wiki/Arsenic_and_Old_Lace_(film) (Wikipedia) and http://www.imdb.com/title/tt0036613/ (Internet Movie Database).

The Director: https://www.facebook.com/beth.honeycutt2 (Facebook).

EDITOR?S NOTE:

Robert W. McDowell is editor and publisher of Triangle Theater Review, a FREE weekly e-mail theatrical newsletter that provides more comprehensive, in-depth coverage of Raleigh, Durham, and Chapel Hill theater than all of the other news media combined. This review is reprinted with permission from Triangle Theater Review.

To start your FREE subscription to this newsletter, e-mail RobertM748@aol.com and type SUBSCRIBE TTR in the Subject: line.

To read all of Robert W. McDowell?s Triangle Theater Review previews and reviews online at Triangle Arts & Entertainment, click http://triangleartsandentertainment.org/author/robert-w-mcdowell/.

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Tagged as: Arsenic and Old Lace, Beth Honeycutt, Garner Performing Arts Center, Joseph O. Kesselring, Towne Players

Source: http://triangleartsandentertainment.org/2012/10/the-towne-players-of-garners-rendition-of-arsenic-and-old-lace-is-an-uproarious-black-comedy/

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Curis Achieves CUDC-907 Milestones Under Its ... - Cancer Kick

LEXINGTON, Mass., Oct. 18, 2012 (GLOBE NEWSWIRE) ? Curis, Inc. (Nasdaq:CRIS), a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that it has achieved the first two development milestones under its agreement with The Leukemia Lymphoma Society (LLS) for the development of CUDC-907, a first-in-class orally-administered small molecule drug candidate inhibitor of phosphatidylinositol-3-kinase (PI3K) and histone deacetylase (HDAC). These milestones include a preclinical development objective, as well as Curis? recent filing of an Investigational New Drug (IND) application to begin Phase I clinical testing of CUDC-907 in patients. As a result, Curis will receive $750,000 in milestone payments under the terms of its agreement with LLS. ?

?The completion of CUDC-907?s preclinical testing and subsequent IND filing is a significant milestone in the development of this important molecule, and we look forward to initiating a Phase I clinical trial in patients with relapsed or refractory lymphomas or multiple myeloma in early 2013,? said Dan Passeri, Curis? President and Chief Executive Officer. ??In preclinical studies, CUDC-907 has demonstrated very potent anti-proliferation activity, and we believe that this approach of disrupting multiple signaling networks with a single-agent drug candidate holds a great deal of promise for patients with advanced cancers.?The upcoming Phase?I dose escalation?study will be extremely important for selecting a dose of CUDC-907 given orally to this specific patient population to be used for further efficacy testing. ?

?We are pleased that Curis? research and development team has successfully completed the preclinical work required to advance CUDC-907 towards clinical testing in patients with lymphomas and multiple myeloma, said Richard Winneker, LLS?s Senior Vice President of Research.??These patients are often in critical need of new treatment options and LLS?s Therapy Acceleration Program (TAP) has provided important capital to companies like Curis to continue advancing novel drug candidates for the treatment of blood cancers.?

About the CUDC-907 Phase I Dose Escalation Trial

The Phase I clinical trial is designed as a standard dose escalation study in which CUDC-907 will be orally administered to patients with relapsed or refractory lymphoma or multiple myeloma at up to four study centers in the United States.?The primary objectives of the trial are to determine the maximum tolerated dose (MTD) and recommended Phase II dose of oral CUDC-907. ?The secondary objectives of this study are to assess safety and tolerability, to assess pharmacokinetics, to evaluate biomarker activity and to assess preliminary anti-cancer activity of CUDC-907 in this patient population.

In the absence of dose limiting toxicity, each patient will receive oral CUDC-907 once daily for a minimum of 21 days of continuous daily dosing (1 cycle), and may continue to receive additional cycles of study treatment until disease progression or other treatment discontinuation criteria are met.

About CUDC-907

CUDC-907 is a potent inhibitor of the Class I PI3K and Class I and II HDAC subtypes, the combination of which Curis scientists believe has synergistic interaction against cancer cells. ?CUDC-907 has demonstrated the ability to suppress multiple nodes of survival and proliferation. ?In addition, preclinical data have shown that CUDC-907 inhibits compensatory pathways often utilized in cancer cells during the emergence of resistance to standard of care agents and induces apoptosis in treated cancer cells.

CUDC-907 exhibits anti-proliferation activity against a broad range of cancer cell types in in vitro studies, including cell lines that exhibit reduced sensitivity to single-target PI3K inhibitors. CUDC-907?s anti-proliferation activity has been demonstrated to be much more potent than that of leading PI3K inhibitors in development. ? CUDC-907 also inhibits tumor growth in preclinical xenograft models of blood cancers as well as solid tumors with K-RAS mutations that exhibit reduced sensitivity to known PI3K inhibitors, indicating that this compound may have broader activity than other leading PI3K inhibitors currently in clinical development.

About the LLS Agreement

Under the agreement, LLS will fund approximately 50% of the direct costs of the development of CUDC-907, up to $4 million.?Curis is currently seeking to advance the molecule into a Phase I dose escalation clinical trial in patients with relapsed or refractory lymphomas or multiple myeloma in early 2013.?If this study is successful, LLS has also agreed to support Curis?s subsequent Phase Ib or Phase IIa study in one or more specific indications as well as Curis? ongoing investigation of biomarkers for CUDC-907 in these diseases.

About The
Leukemia Lymphoma Society

The Leukemia Lymphoma Society ? (LLS) is the world?s largest voluntary health agency dedicated to blood cancer. ?The LLS mission: Cure leukemia, lymphoma, Hodgkin?s disease and myeloma, and improve the quality of life of patients and their families. ?LLS funds lifesaving blood cancer research around the world and provides free information and support services. ?Founded in 1949 and headquartered in White Plains, NY, LLS has chapters throughout the United States and Canada. ?To learn more, visit www.LLS.org or contact the Information Resource Center at (800) 955-4572, Monday through Friday, 9 a.m. to 6 p.m. ET. www.lls.org.

About Curis, Inc.

Curis is a drug development company that is committed to leveraging its innovative signaling pathway drug technologies to seek to create new targeted small molecule drug candidates for cancer. ?Curis is building upon its previous experiences in targeting signaling pathways, including in the Hedgehog pathway, in its effort to develop proprietary targeted cancer programs. ?For more information, visit Curis? website at www.curis.com.

The Curis, Inc. logo is available at http://www.globenewswire.com/newsroom/prs/?pkgid=11347

Curis Cautionary Statement: This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including without limitation statements regarding Curis? expectations regarding the potential benefits of the oral formulation of CUDC-907.?Forward-looking statements used in this press release may contain the words ?believes?, ?expects?, ?anticipates?, ?plans?, ?seeks?, ?estimates?, ?assumes?, ?will?, ?may,? ?could? or similar expressions. ?These forward-looking statements are not guarantees of future performance and involve risks, uncertainties, assumptions and other important factors that may cause actual results to be materially different from those indicated by such forward-looking statements. ?For example, Curis may not be able to successfully enroll patients in this Phase I clinical trial or may otherwise experience delays, setbacks and failures in its clinical development of CUDC-907, and the oral form of CUDC-907 may cause unexpected toxicities.

Curis also faces other important risks relating to its business, operations, financial condition and future prospects generally, that are discussed in its Quarterly Report on Form 10-Q for the quarter ended June 30, 2012 and other filings that it periodically makes with the Securities and Exchange Commission.?

In addition, any forward-looking statements represent the views of Curis only as of today and should not be relied upon as representing Curis? views as of any subsequent date. Curis disclaims any intention or obligation to update any of the forward-looking statements after the date of this press release whether as a result of new information, future events or otherwise.

CONTACT: Michael P. GrayChief Financial and Chief Operating Officer          Curis, Inc.          617-503-6632          mgray@curis.comAndrea Greif          Director of Public Relations          The Leukemia  Lymphoma Society          (914) 821-8958          andrea.greif@lls.org

Source: Curis, Inc.

Article source: http://www.nasdaq.com/article/curis-achieves-cudc-907-milestones-under-its-agreement-with-the-leukemia--lymphoma-society-20121018-00214

Source: http://cancerkick.com/2012/10/18/curis-achieves-cudc-907-milestones-under-its-agreement-with-the-leukemia/

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Thursday, October 18, 2012

Too late to stop global warming by cutting emissions? Scientists argue for adaption policies

ScienceDaily (Oct. 17, 2012) ? Governments and institutions should focus on developing adaption policies to address and mitigate against the negative impact of global warming, rather than putting the emphasis on carbon trading and capping greenhouse-gas emissions, argue Johannesburg-based Wits University geoscientist Dr Jasper Knight and Dr Stephan Harrison from the University of Exeter in the United Kingdom.

"At present, governments' attempts to limit greenhouse-gas emissions through carbon cap-and-trade schemes and to promote renewable and sustainable energy sources are prob?ably too late to arrest the inevitable trend of global warming," the scientists write in a paper published online in the scientific journal, Nature Climate Change, on Monday, Oct. 14, 2012.

The paper, entitled "The Impacts of climate change on terrestrial Earth surface systems," is published in the Perspective section of Nature Climate Change and argues that much less attention is paid by policymakers to monitor, model and manage the impacts of climate change on the dynamics of Earth surface systems, including glaciers, rivers, mountains and coasts. "This is a critical omis?sion, as Earth surface systems provide water and soil resources, sustain ecosystem services and strongly influence biogeochemical climate feedbacks in ways that are as yet uncertain," the scientists write.

Knight and Harrison want governments to focus more on adaption policies because future impacts of global warming on land-surface stability and the sediment fluxes associated with soil erosion, river down-cutting and coastal erosion are relevant to sustainability, biodiversity and food security. Monitoring and modelling soil erosion loss, for example, are also means by which to examine problems of carbon and nutri?ent fluxes, lake eutrophication, pollutant and coliform dispersal, river siltation and other issues. An Earth-systems approach can actively inform on these cognate areas of environmental policy and planning.

According to the scientists, Earth surface systems' sensitivity to climate forcing is still poorly understood. Measuring this geomorphological sensi?tivity will identify those systems and environments that are most vulnerable to climatic disturbance, and will enable policymakers and managers to prioritise action in these areas.

"This is particularly the case in coastal environments, where rocky and sandy coastlines will yield very different responses to climate forcing, and where coastal-zone management plans are usually based on past rather than future climatic patterns," they argue.

The recent Intergovernmental Panel on Climate Change special report on extreme events and disasters and the forthcoming fifth assessment report, due 2013, include more explicit statements of the role of Earth surface systems in responding to and influencing climate forcing.

"However, monitoring of the response of these systems to climate forcing requires decadal-scale data sets of instrumented basins and under different climatic regimes worldwide. This will require a con-siderable international science effort as well as commitment from national governments," Knight and Harrison urge.

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Story Source:

The above story is reprinted from materials provided by University of the Witwatersrand, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jasper Knight, Stephan Harrison. The impacts of climate change on terrestrial Earth surface systems. Nature Climate Change, 2012; DOI: 10.1038/nclimate1660

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/ABNNXDCXBIg/121017102943.htm

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